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Design considerations for pulsed-flow comprehensive two-dimensional GC: Dynamic flow model approach

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Version 2 2024-06-05, 00:52
Version 1 2018-10-02, 11:12
journal contribution
posted on 2024-06-05, 00:52 authored by PMA Harvey, Robert ShellieRobert Shellie, PR Haddad
A dynamic flow model, which maps carrier gas pressures and carrier gas flow rates through the first dimension separation column, the modulator sample loop, and the second dimension separation column(s) in a pulsed-flow modulation comprehensive two-dimensional gas chromatography (PFM-GC×GC) system is described. The dynamic flow model assists design of a PFM-GC×GC modulator and leads to rapid determination of pneumatic conditions, timing parameters, and the dimensions of the separation columns and connecting tubing used to construct the PFM-GC×GC system. Three significant innovations are introduced in this manuscript, which were all uncovered by using the dynamic flow model. A symmetric flow path modulator improves baseline stability, appropriate selection of the flow restrictors in the first dimension column assembly provides a generally more stable and robust system, and these restrictors increase the modulation period flexibility of the PFM-GC×GC system. The flexibility of a PFMGC×GC system resulting from these innovations is illustrated using the same modulation interface to analyze Special Antarctic Blend (SAB) diesel using 3 s and 9 s modulation periods.

History

Journal

Journal of Chromatographic Science

Volume

48

Pagination

245-250

Location

Oxford, Eng.

Open access

  • Yes

ISSN

0021-9665

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

4

Publisher

Oxford University Press

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