Design of endoperoxides with anti-Candida activity
Version 2 2024-06-17, 12:02
Version 1 2015-08-21, 15:04
journal contribution
posted on 2024-06-17, 12:02 authored by TD Avery, Peter Macreadie, BW Greatrex, TV Robinson, DK Taylor, IG MacreadieBroad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.
History
Journal
Bioorganic & medicinal chemistryVolume
15Pagination
36-42Location
Amsterdam, The NetherlandsPublisher DOI
ISSN
0968-0896Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2007, ElsevierIssue
1Publisher
ElsevierUsage metrics
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Keywords
AnimalsAntifungal AgentsCHO CellsCandida albicansCell ProliferationCricetinaeDrug DesignErythrocytesHumansMicrobial Sensitivity TestsMolecular ConformationPeroxidesStereoisomerismStructure-Activity Relationship030503 Organic Chemical Synthesis860803 Human Pharmaceutical Treatments (e.g. Antibiotics)Centre for Integrative EcologySchool of Life and Environmental Sciences
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