Design of endoperoxides with anti-Candida activity
Version 2 2024-06-17, 12:02Version 2 2024-06-17, 12:02
Version 1 2015-08-21, 15:04Version 1 2015-08-21, 15:04
journal contribution
posted on 2024-06-17, 12:02authored byTD Avery, Peter Macreadie, BW Greatrex, TV Robinson, DK Taylor, IG Macreadie
Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.