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Design of enzyme micelles with controllable concavo-convex micromorphologies for highly enhanced stability and catalytical activity
journal contribution
posted on 2018-03-01, 00:00 authored by T Chen, Y Xu, Wenrong YangWenrong Yang, A Li, Y Wang, J Sun, J LiuConcavo-convex micelles with controllable sizes and nanostructures are prepared via self-assembling polymer-enzyme (e.g., shellac enzyme) conjugates with heterogeneous polymer chains, which exhibit higher enzyme stability (300%) and bioactivity (760%) comparing with the well-defined ones. The applied amphiphilic and negatively charged copolymer, poly (methyl methacrylate)-block-poly (sodium p-styrene sulfonate), is synthesized via reversible addition-fragmentation chain transfer polymerization to modify shellac enzyme and immobilize the enzyme bioactivity inducer by covalent conjugation and electrostatic attraction, respectively. The degradation test of catechol confirms the application potential of as-prepared micelles as an efficient and economical decontaminant.
History
Journal
Macromolecular bioscienceVolume
18Issue
3Article number
1700312Pagination
1 - 9Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
ISSN
1616-5187eISSN
1616-5195Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2018, WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimUsage metrics
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No categories selectedKeywords
catalytical activitycatechol degradationconcavo-convex micellesshellac enzymestabilityScience & TechnologyLife Sciences & BiomedicineTechnologyPhysical SciencesBiochemistry & Molecular BiologyMaterials Science, BiomaterialsPolymer ScienceMaterials ScienceWHITE-ROT FUNGILACCASEPOLYMERIZATIONEFFICIENTPROTEINDECONTAMINATIONNANOPARTICLEBIOCATALYSTSDELIVERYRAFT
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