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Design of sustained release tablet containing fucoidan

Version 2 2024-06-04, 06:07
Version 1 2017-11-10, 11:23
journal contribution
posted on 2015-01-01, 00:00 authored by T T-D Tran, D K-P Ngo, T V Vo, Phuong TranPhuong Tran
The study introduced a new therapeutic agent, fucoidan, which can offer potential medical treatments including anti-inflammatory and anti-coagulant activities, as well as anti-proliferative effects on cancer cells. Fucoidan was included in sustained release formulations expected for an effective plasma drug concentration for approximately 24 h. The matrices based on the two polymers hydroxypropyl methycellulose (HPMC) and polyethylene oxide (PEO) were prepared with various ratios between the polymers and fucoidan. The dissolution profiles of various matrix tablets performed in enzyme-free simulated intestinal fluid (pH 6.8) for 24 h indicated a higher potential of PEO-based matrix tablets in sustaining release of fucoidan. The swelling and erosion of the tablets were also characterized to elucidate the difference among those dissolution profiles.

History

Journal

Current drug delivery

Volume

12

Issue

2

Pagination

231 - 237

Publisher

Bentham Science Publishers

Location

Beijing, China

eISSN

1875-5704

Language

eng

Publication classification

C Journal article; C1.1 Refereed article in a scholarly journal

Copyright notice

[2015, Bentham Science Publishers]