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Designing a Multicomponent Spray-Dried Formulation Platform for Pulmonary Delivery of Biomacromolecules: The Effect of Polymers on the Formation of an Amorphous Matrix for Glassy State Stabilization of Biomacromolecules

Version 2 2024-06-04, 15:47
Version 1 2020-05-13, 16:07
journal contribution
posted on 2024-06-04, 15:47 authored by T Sou, MP McIntosh, LM Kaminskas, RJ Prankerd, David Morton
Non-reducing sugars such as mannitol are widely studied as excipients for spray-dried pharmaceutical formulations. In contrast, the present study investigated the use of a range of polymers for the production of an amorphous glassy carrier platform for pulmonary delivery of potent biomacromolecules. Two different natural polysaccharides, inulin and dextran, and the synthetic polymer polyvinylpyrrolidone (PVP) were combined with leucine using spray-drying. In addition, the effect of these polymers in combination with mannitol was studied. The results showed that leucine was a very effective particle formation agent that substantially improved processing yields of the spray-dried polymer-leucine-based formulations and formed high-rugosity particles with high fine particle fractions. The work indicated the potential utilities of these multicomponent systems as a novel dry powder formulation platform for pulmonary delivery of various biomacromolecules. © 2013 Copyright Taylor and Francis Group, LLC.

History

Journal

Drying Technology

Volume

31

Pagination

1451-1458

Location

London, Eng.

ISSN

0737-3937

eISSN

1532-2300

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

13-14

Publisher

Taylor & Francis

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