Detection of a major gene predisposing to human T lymphotropic virus type I infection in children among an endemic population of African origin
journal contributionposted on 2000-08-01, 00:00 authored by S Plancoulaine, A Gessain, M Joubert, P Tortevoye, Isabelle Jeanne, A Talarmin, G de Thé, L Abel
Human T lymphotropic virus type I (HTLV-I) is a human oncoretrovirus that causes an adult T cell leukemia/lymphoma and a chronic neuromyelopathy. To investigate whether familial aggregation of HTLV-I infection (as determined by specific seropositive status) could be explained in part by genetic factors, we conducted a large genetic epidemiological survey in an HTLV-I-endemic population of African origin from French Guiana. All of the families in 2 villages were included, representing 83 pedigrees with 1638 subjects, of whom 165 (10.1%) were HTLV-I seropositive. The results of segregation analysis are consistent with the presence of a dominant major gene predisposing to HTLV-I infection, in addition to the expected familial correlations (mother-offspring, spouse-spouse) due to the virus transmission routes. Under this genetic model, approximately 1. 5% of the population is predicted to be highly predisposed to HTLV-I infection, and almost all seropositive children <10 years of age are genetic cases, whereas most HTLV-I seropositive adults are sporadic cases.
JournalJournal of infectious diseases
Pagination405 - 412
PublisherOxford University Press
Publication classificationCN.1 Other journal article
Copyright notice2000, Infectious Diseases Society of America.
CategoriesNo categories selected
AdolescentAdultAfricaAge FactorsChildChild, PreschoolEndemic DiseasesFemaleFrench GuianaGenetic Predisposition to DiseaseHTLV-I InfectionsHumansLogistic ModelsMaleMiddle AgedPedigreePenetranceSeroepidemiologic StudiesScience & TechnologyLife Sciences & BiomedicineImmunologyInfectious DiseasesMicrobiologyCELL LEUKEMIA-VIRUSTROPICAL SPASTIC PARAPARESISREGRESSIVE LOGISTIC-MODELSHTLV-IHIV-1 INFECTIONANTIBODY-RESPONSECARRIER MOTHERSPROVIRAL LOADTRANSMISSIONRATS