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Determination of psilocin and psilocybin using flow injection analysis with acidic potassium permanganate and tris(2,2’-bipyridyl) ruthenium(II) chemiluminescence detection respectively

journal contribution
posted on 2005-08-15, 00:00 authored by N Anastos, Neil BarnettNeil Barnett, S Lewis, N Gathergood, Peter Scammells, N Sims
A simple, rapid and sensitive method for the determination of psilocin and psilocybin is described. This is the first report on the determination of psilocin and psilocybin using flow injection analysis with acidic potassium permanganate and tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence. The limits of detection (signal-to-noise ratio = 3) are 9 × 10−10 M and 3 × 10−10 M for psilocin and psilocybin, respectively.A concise synthetic route for psilocin in three steps from readily available starting materials is also described. The structures were elucidated on the basis of spectroscopic data.

History

Journal

Talanta

Volume

67

Issue

2

Pagination

354 - 359

Publisher

Elsevier BV

Location

Amsterdam, Netherlands

ISSN

0039-9140

eISSN

1873-3573

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2005, Elsevier BV