Determination of ranitidine and salbutamol by flow injection analysis with chemiluminescence detection

Flow injection analysis methodology is reported for the determination of ranitidine and salbutamol (in pharmaceutical formulations) based on their chemiluminescent reactions with tris(2,2'-bipyridyl)ruthenium(III) and acidic potassium permanganate, respectively. While the log-log calibration function for ranitidine showed significant non linearity, the precision (measured as relative standard deviation) was 1.7% (n=6 1x10-5M) and the detection limit (3σ blank) was 6x10-7M. A linear log-log calibration function was obtained for salbutamol, the precision being 2.7% (n=6; 1x10-7M) with a detection limit (signal to noise ratio=3) of 2.5x10-8M. Copyright (C) 1999 Elsevier Science B.V.