File(s) under permanent embargo
Determination of ranitidine and salbutamol by flow injection analysis with chemiluminescence detection
journal contributionposted on 1999-03-29, 00:00 authored by Neil BarnettNeil Barnett, B J Hindson, S W Lewis
Flow injection analysis methodology is reported for the determination of ranitidine and salbutamol (in pharmaceutical formulations) based on their chemiluminescent reactions with tris(2,2'-bipyridyl)ruthenium(III) and acidic potassium permanganate, respectively. While the log-log calibration function for ranitidine showed significant non linearity, the precision (measured as relative standard deviation) was 1.7% (n=6 1x10-5M) and the detection limit (3σ blank) was 6x10-7M. A linear log-log calibration function was obtained for salbutamol, the precision being 2.7% (n=6; 1x10-7M) with a detection limit (signal to noise ratio=3) of 2.5x10-8M. Copyright (C) 1999 Elsevier Science B.V.