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Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound
journal contribution
posted on 2017-09-01, 00:00 authored by S J Blackwood, R M Dwyer, E A Bradley, Michelle KeskeMichelle Keske, S M Richards, S RattiganMost methods of assessing flowmotion (rhythmic oscillation of blood flow through tissue) are limited to small sections of tissue and are invasive in tissues other than skin. To overcome these limitations, we adapted the contrast-enhanced ultrasound (CEUS) technique to assess microvascular flowmotion throughout a large region of tissue, in a non-invasive manner and in real time. Skeletal muscle flowmotion was assessed in anaesthetised Sprague Dawley rats, using CEUS and laser Doppler flowmetry (LDF) for comparison. Wavelet transformation of CEUS and LDF data was used to quantify flowmotion. The α-adrenoceptor antagonist phentolamine was infused to predictably blunt the neurogenic component of flowmotion. Both techniques identified similar flowmotion patterns, validating the use of CEUS to assess flowmotion. This study demonstrates for the first time that the novel technique of CEUS can be adapted for determination of skeletal muscle flowmotion in large regions of skeletal muscle.
History
Journal
Ultrasound in medicine & biologyVolume
43Issue
9Pagination
2013 - 2023Publisher
ElsevierLocation
Philadelphia, Pa.Publisher DOI
ISSN
0301-5629eISSN
1879-291XLanguage
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, World Federation for Ultrasound in Medicine & BiologyUsage metrics
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