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Developmental strategies of curcumin solid dispersions for enhancing bioavailability
Background:
Although curcumin has been demonstrated to be beneficial in treating various diseases,
its low solubility, chemical stability and bioavailability limit its application, especially in cancer therapy.
Methods:
Solid dispersions have been utilized in the last few decades to improve the bioavailability and stability
of curcumin.
Results:
However, there is a lack of summaries and classifications of the methods for preparing curcumin with
this technology. The current review aims to overview the strategies used to develop solid dispersions containing
curcumin for improving drug delivery. The classification of techniques for creating solid dispersions for curcumin
was summarized, including systems for protecting curcumin degradation despite its chemical stability. The
applications of advanced nanotechnologies in recent studies of solid dispersions were also discussed to explain
the roles of nanoparticles in formulations.
Conclusion:
This overview of recent developments in formulating solid dispersions for improving curcumin
bioavailability will contribute to future studies of curcumin for clinical development.
History
Journal
Anti-Cancer Agents in Medicinal ChemistryVolume
20Issue
16Pagination
1874 - 1882Publisher
Bentham Science Publishers Ltd.Location
San Francisco, Calif.Publisher DOI
ISSN
1871-5206eISSN
1875-5992Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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