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Dextran reduces embolic signals after carotid endarterectomy
journal contribution
posted on 2001-10-01, 00:00 authored by C R Levi, J L Stork, B R Chambers, A L Abbott, H M Cameron, Anna PeetersAnna Peeters, J P Royle, A K Roberts, G Fell, M C Hoare, A T Chan, G A DonnanOne hundred fifty patients undergoing carotid endarterectomy were randomly assigned to receive intravenous 10% dextran 40 or placebo. Transcranial Doppler monitoring of the ipsilateral middle cerebral artery 0 to 1 hour postoperatively detected embolic signals in 57% of placebo and 42% of dextran patients, with overall embolic signal counts 46% less for dextran (p = 0.052). Two to 3 hours postoperatively, embolic signals were present in 45% of placebo and 27% of dextran patients, with embolic signal counts 64% less for dextran (p = 0.040). We conclude that dextran reduces embolic signals within 3 hours of CEA.
History
Journal
Annals of neurologyVolume
50Issue
4Pagination
544 - 547Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
ISSN
0364-5134Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2001, Wiley-LissUsage metrics
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No categories selectedKeywords
AgedAnticoagulantsCarotid StenosisDextransEndarterectomy, CarotidFemaleHumansInjections, IntravenousIntracranial EmbolismMaleMiddle AgedPostoperative ComplicationsUltrasonography, Doppler, TranscranialScience & TechnologyLife Sciences & BiomedicineClinical NeurologyNeurosciencesNeurosciences & NeurologyTRANSCRANIAL DOPPLER ULTRASONOGRAPHYMICROEMBOLISMEMBOLIZATIONSTROKE
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