File(s) under permanent embargo
Diabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaboration
journal contribution
posted on 2012-01-01, 00:00 authored by Y Murakami, Rachel HuxleyRachel Huxley, T H Lam, R Tsukinoki, X Fang, H C Kim, M WoodwardObjective: To examine the effects of diabetes on coronary heart disease, ischemic and hemorrhagic stroke and cardiovascular disease according to category of body mass index. Methods: Data on 161,161 men and women from 31 cohorts (baseline years, 1966-99; mean follow-up, 2-24. years) from the Asia Pacific Cohort Studies Collaboration were analyzed using Cox regression, stratified by sex and study and adjusted for age, systolic blood pressure and smoking. Diabetes was self-reported in all but one study. Body mass index was divided into five categories according to the World Health Organization Asian criteria. Results: The hazard ratio (diabetes v. not) for cardiovascular disease was 1.83 (95% confidence interval, 1.66-2.01). Across body mass index categories, this hazard ratio did not change significantly (p = 0.19). Similar lack of difference across body mass index groups was found for coronary heart disease (p = 0.33), ischemic stroke (p = 0.97) and hemorrhagic stroke (p = 0.98). Conclusions: Body mass index does not modify the effect of diabetes on major cardiovascular outcomes.
History
Journal
Preventive medicineVolume
54Issue
1Pagination
38 - 41Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0091-7435eISSN
1096-0260Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2011, ElsevierUsage metrics
Categories
Keywords
Science & TechnologyLife Sciences & BiomedicinePublic, Environmental & Occupational HealthMedicine, General & InternalGeneral & Internal MedicineEffect modificationDiabetesBody mass indexCoronary heart diseaseStrokeCardiovascular diseasePooled analysisCARDIOVASCULAR-DISEASEBLOOD-GLUCOSEMORTALITYREGIONAsia Pacific Cohort Studies Collaboration