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Diabetes mellitus following renal transplantation: clinical and pharmacological considerations for the elderly patient
journal contribution
posted on 2017-08-01, 00:00 authored by D Langsford, A Steinberg, Karen DwyerKaren DwyerPost-transplant diabetes mellitus occurs in 30-50% of cases during the first year post-renal transplantation. It is associated with increased morbidity, mortality and healthcare costs. Risk factors include age and specific immunosuppression regimens. At the same time, renal transplantation is increasingly indicated in elderly (aged >65 years) patients as this proportion of older patients in the prevalent dialysis population has increased. The immune system and β cells undergo senescence and this impacts on the risk for developing post-transplant diabetes and our ability to prevent such development. It may, however, be possible to identify patients at risk of developing post-transplant diabetes, enabling treatment protocols that prevent or reduce the impact of post-transplant diabetes. Much work remains to be completed in this area and is facilitated by the growing base of knowledge regarding the pathophysiology of post-transplant diabetes. Should post-transplant diabetes develop, there are a range of treatment options available. There is increasing interest in using newer agents, although their safety and efficacy in transplant recipients remains to be conclusively established.
History
Journal
Drugs and agingVolume
34Issue
8Pagination
589 - 601Publisher
SpringerLocation
Berlin, GermanyPublisher DOI
eISSN
1179-1969Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, SpringerUsage metrics
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No categories selectedKeywords
Age FactorsAgedBlood GlucoseDiabetes MellitusGlucose Tolerance TestHumansHypoglycemic AgentsImmunosuppressionKidney TransplantationMaleRisk FactorsScience & TechnologyLife Sciences & BiomedicineGeriatrics & GerontologyPharmacology & PharmacyGLUCOSE-METABOLISM DISORDERSBETA-CELL FUNCTIONKIDNEY-TRANSPLANTATIONLONG-TERMGLYCEMIC CONTROLDOUBLE-BLINDINSULIN SENSITIVITYRANDOMIZED-TRIALACUTE REJECTIONRISK-FACTORS
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