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Differential activation of brain areas in children with developmental coordination disorder during tasks of manual dexterity: An ALE meta-analysis

Version 2 2024-06-06, 09:09
Version 1 2018-01-31, 08:57
journal contribution
posted on 2024-06-06, 09:09 authored by Ian FuelscherIan Fuelscher, Karen CaeyenberghsKaren Caeyenberghs, Peter EnticottPeter Enticott, J Williams, Jarrad LumJarrad Lum, Christian HydeChristian Hyde
Recent neuroimaging studies have reported atypical neural activation in children with Developmental Coordination Disorder (DCD) during tasks assessing manual dexterity. However, small sample sizes and subtle differences in task parameters have led to inconsistent findings, rendering interpretation difficult. The aim of the present meta-analysis was to quantitatively summarize this body of evidence using activation likelihood estimation (ALE) analysis to identify reliable regions of differential neural activation in children with DCD, compared to age-matched controls. Seven studies that adopted fMRI to compare children with and without DCD during manual performance were identified following a literature search. All were included in the ALE analysis. Compared to controls, children with DCD showed reduced activation during a manual dexterity task in the middle frontal gyrus, superior frontal gyrus, cerebellum, supramarginal gyrus, and inferior parietal lobule. Children with DCD showed greater activation in parts of the thalamus. Findings provide much needed clarification into the possible neural contributors to atypical manual dexterity in DCD and highlight the need for neuroimaging studies to include manual performance outcomes.

History

Journal

Neuroscience and Biobehavioral Reviews

Volume

86

Pagination

77-84

Location

United States

ISSN

0149-7634

eISSN

1873-7528

Language

English

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2018, Elsevier

Publisher

PERGAMON-ELSEVIER SCIENCE LTD