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Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice
journal contribution
posted on 2018-09-01, 00:00 authored by X-F Guo, Andrew SinclairAndrew Sinclair, Gunveen KaurGunveen Kaur, D LiThe aim of the present study was to assess and compare the effects of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) supplementation on lipid metabolism in 4 month-old male C57BL/6J mice fed a high-fat diet. The high-fat fed mice showed evidence of fatty liver, obesity and insulin resistance after being on the high-fat diet for 6 weeks compared with the control low-fat diet fed mice. Supplementation of the high-fat diet with either EPA, DPA or DHA prevented the fatty liver, prevented high serum cholesterol and serum glucose and prevented high liver cholesterol levels. DPA (but not EPA or DHA) was associated with a significantly improved homeostasis model assessment of insulin resistance (HOMA-IR) compared with the high-fat fed mice. Supplementation with DPA and DHA both prevented the decreased serum adiponectin levels, compared with EPA and the high-fat diet. In addition, supplementation with DPA and DHA both prevented the increased serum alanine aminotransferase (ALT) levels compared with EPA and the high-fat group, which can be attributed to down-regulation of TLR-4/NF-κB signaling pathway and decreasing lipogenesis in the liver. Therefore, DPA and DHA seem to exert similar effects in cardio-metabolic protection against the high-fat diet and these effects seem to be different to those of EPA.
History
Journal
Prostaglandins, leukotrienes and essential fatty acidsVolume
136Pagination
47 - 55Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0952-3278eISSN
1532-2823Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, Elsevier LtdUsage metrics
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No categories selectedKeywords
Docosahexaenoic acidDocosapentaenoic acidEicosapentaenoic acidGlucose and lipid metabolismInflammatory markersScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyCell BiologyEndocrinology & MetabolismMECHANISMS LINKING OBESITYINSULIN-RESISTANCEHIGH-CARBOHYDRATEFETUIN-AADIPONECTINACIDSOMEGA-3-FATTY-ACIDSINFLAMMATIONSENSITIVITYADIPOSITY
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