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Differential response to resistance training in CHF according to ACE genotype

journal contribution
posted on 2011-06-16, 00:00 authored by A Williams, M Anderson, Steve SeligSteve Selig, M Carey, M Febbraio, A Hayes, D Toia, S Harrap, D Hare
Background : The Angiotensin Converting Enzyme (ACE) gene may influence the risk of heart disease and the response to various forms of exercise training may be at least partly dependent on the ACE genotype. We aimed to determine the effect of ACE genotype on the response to moderate intensity circuit resistance training in chronic heart failure (CHF) patients.

Methods :
The relationship between ACE genotype and the response to 11 weeks of resistance exercise training was determined in 37 CHF patients (New York Heart Association Functional Class = 2.3 ± 0.5; left ventricular ejection fraction 28 ± 7%; age 64 ± 12 years; 32:5 male:female) who were randomised to either resistance exercise (n = 19) or inactive control group (n = 18). Outcome measures included VO2peak power output and muscle strength and endurance. ACE genotype was determined using standard methods.

Results :
At baseline, patients who were homozygous for the I allele had higher VO2peak (p = 0.02) and peak power (p = 0.003) compared to patients who were homozygous for the D allele. Patients with the D allele, who were randomised to resistance training, compared to non-exercising controls, had greater peak power increases (ID p < 0.001; DD p < 0.001) when compared with patients homozygous for the I allele, who did not improve. No significant genotype-dependent changes were observed in VO2peak, muscle strength, muscle endurance or lactate threshold.

Conclusion :
ACE genotype may have a role in exercise tolerance in CHF and could also influence the effectiveness of resistance training in this condition.

History

Journal

International journal of cardiology

Volume

149

Issue

3

Pagination

330 - 334

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0167-5273

eISSN

1874-1754

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2011, Elsevier

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