savira-dihydrosphingosinedriven-2021.pdf (3.13 MB)
Download fileDihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts
journal contribution
posted on 2021-08-01, 00:00 authored by R R Magaye, Feby SaviraFeby Savira, X Xiong, K Huynh, P J Meikle, C Reid, B L Flynn, D Kaye, D Liew, B H WangDihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts
History
Journal
IJC Heart and VasculatureVolume
35Article number
100837Pagination
1 - 11Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
Link to full text
ISSN
2352-9067eISSN
2352-9067Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Categories
Keywords
1-PHOSPHATECardiac & Cardiovascular SystemsCardiac fibroblastsCardiovascular System & CardiologyCELLSCERAMIDECollagen synthesisDIHYDROCERAMIDE DESATURASEDihydrosphingosineGROWTHLife Sciences & BiomedicinePHOSPHORYLATIONPLASMARECEPTORScience & TechnologySphingolipidSPHINGOSINESPHINGOSINE-1-PHOSPHATETGF betaAkt, protein kinase BCTGF, connective tissue growth factorCer, ceramideCer1P, ceramide 1 phosphateColl1a1, collagen 1a1Degs1, dihydroceramide desaturase 1 geneDes-1, dihydroceramide desaturase 1 enzymeECM, extracellular matrix inhibitor of nuclear kappa B (NFKβ) kinase alpha and beta (IKKα\/β)MA3PK, mitogen activated protein kinase kinase kinaseMAPK, mitogren activated protein kinaseMI, myocardial infarctMMP2, matrix metalloproteinase 2NCF, neonatal cardiac fibroblastsRPS6, ribosomal protein S6S1P, sphingosine-1 PhosphateS1PR1, sphingosine -1-phosphate receptor 1S1PRs, sphingosine 1 phosphate receptor 1-5SK1, sphingosine kinase 1Sph, sphingosineTAK1, transforming growth factor β activating kinase 1TGFβTGFβ, transforming growth factor βTIMP1, tissue inhibitor of metalloproteinase 1d7dhSph, deuterated dihydrosphingosinedhCer, dihydroceramidedhS1P, dihydrosphingosine 1 phosphatemTOR, mammalian target for rapamycin