Deakin University
Browse
savira-dihydrosphingosinedriven-2021.pdf (3.13 MB)

Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts

Download (3.13 MB)
journal contribution
posted on 2021-08-01, 00:00 authored by R R Magaye, Feby SaviraFeby Savira, X Xiong, K Huynh, P J Meikle, C Reid, B L Flynn, D Kaye, D Liew, B H Wang
Dihydrosphingosine driven enrichment of sphingolipids attenuates TGFβ induced collagen synthesis in cardiac fibroblasts

History

Journal

IJC Heart and Vasculature

Volume

35

Article number

100837

Pagination

1 - 11

Publisher

Elsevier

Location

Amsterdam, The Netherlands

Publisher DOI

Link to full text

ISSN

2352-9067

eISSN

2352-9067

Language

eng

Author URL

Publication classification

C1 Refereed article in a scholarly journal

Usage metrics

    Research Publications

    Categories

    No categories selected

    Keywords

    1-PHOSPHATECardiac & Cardiovascular SystemsCardiac fibroblastsCardiovascular System & CardiologyCELLSCERAMIDECollagen synthesisDIHYDROCERAMIDE DESATURASEDihydrosphingosineGROWTHLife Sciences & BiomedicinePHOSPHORYLATIONPLASMARECEPTORScience & TechnologySphingolipidSPHINGOSINESPHINGOSINE-1-PHOSPHATETGF betaAkt, protein kinase BCTGF, connective tissue growth factorCer, ceramideCer1P, ceramide 1 phosphateColl1a1, collagen 1a1Degs1, dihydroceramide desaturase 1 geneDes-1, dihydroceramide desaturase 1 enzymeECM, extracellular matrix inhibitor of nuclear kappa B (NFKβ) kinase alpha and beta (IKKα\/β)MA3PK, mitogen activated protein kinase kinase kinaseMAPK, mitogren activated protein kinaseMI, myocardial infarctMMP2, matrix metalloproteinase 2NCF, neonatal cardiac fibroblastsRPS6, ribosomal protein S6S1P, sphingosine-1 PhosphateS1PR1, sphingosine -1-phosphate receptor 1S1PRs, sphingosine 1 phosphate receptor 1-5SK1, sphingosine kinase 1Sph, sphingosineTAK1, transforming growth factor β activating kinase 1TGFβTGFβ, transforming growth factor βTIMP1, tissue inhibitor of metalloproteinase 1d7dhSph, deuterated dihydrosphingosinedhCer, dihydroceramidedhS1P, dihydrosphingosine 1 phosphatemTOR, mammalian target for rapamycin

    Licence

    All Rights Reserved

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC