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Dimerization of retroviral RNA genomes : an inseparable pair

journal contribution
posted on 2004-06-01, 00:00 authored by J C Paillart, M Shehu-Xhilaga, R Marquet, Johnson Mak
Many viruses carry more than one segment of nucleic acid into the virion particle, but retroviruses are the only known group of viruses that contain two identical (or nearly identical) copies of the RNA genome within the virion. These RNA genomes are non-covalently joined together through a process known as genomic RNA dimerization. Uniquely, the RNA dimerization of the retroviral genome is of crucial importance for efficient retroviral replication. In this article, our current understanding of the relationship between retroviral genome conformation, dimerization and replication is reviewed.

History

Journal

Nature reviews. Microbiology

Volume

2

Issue

6

Pagination

461 - 472

Publisher

Nature Publishing Group

Location

London, England

ISSN

1740-1526

eISSN

1740-1534

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2004, Nature Publishing Group