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Disposition of intravenous theophylline-7-acetic acid in rabbits

journal contribution
posted on 1980-04-01, 00:00 authored by Julie OwensJulie Owens, K Nakatsu
Theophylline-7-acetic acid (T7AA) was administered intravenously to rabbits so that its distribution and rate of elimination could be ascertained. The analytical techniques used were liquid scintillation counting (14C) and high pressure liquid chromatography. T7AA was eliminated rapidly in the urine; the T 1/2 was 11.6 min. This drug appears to accumulate in the kidney because after 60 min, approximately 15 per cent of the intravenous dose was found in that organ.

History

Journal

Biopharmaceutics and drug disposition

Volume

1

Season

April/June

Pagination

179-186

Location

Chichester, Eng.

ISSN

0142-2782

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1980, Wiley

Issue

4

Publisher

Wiley