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Do age-related differences in aperiodic neural activity explain differences in resting EEG alpha?
journal contribution
posted on 2023-02-10, 04:15 authored by A Merkin, S Sghirripa, L Graetz, AE Smith, B Hordacre, R Harris, Julia Pitcher, J Semmler, NC Rogasch, M GoldsworthyAlpha-band oscillatory activity in human electroencephalography (EEG) becomes slower and lower in amplitude with advanced age. However, the influence of aperiodic activity on these measures has received little consideration. We investigated whether age-related differences in aperiodic activity explains differences in resting EEG peak alpha frequency and power. We assessed aperiodic activity in 85 younger and 92 older adults by fitting the 1/f-like background activity evident in EEG power spectra using the spectral parameterization (“specparam”) algorithm. Across the scalp, the aperiodic exponent and offset were smaller in older compared to younger participants, reflecting a flatter 1/f-like slope and a downward broadband shift in power spectra with age. After correcting for aperiodic activity, peak alpha frequency remained slower in older adults; however, peak alpha power no longer differed statistically between age groups. The large sample size utilized in this study, as well as the depth of analysis, provides further evidence that the aperiodic component of the resting EEG signal is altered with aging and should be considered when investigating neural oscillatory activity.
History
Journal
Neurobiology of AgingVolume
121Pagination
78-87Location
United StatesPublisher DOI
ISSN
0197-4580eISSN
1558-1497Language
EnglishPublication classification
C1 Refereed article in a scholarly journalPublisher
ELSEVIER SCIENCE INCUsage metrics
Keywords
Science & TechnologyLife Sciences & BiomedicineGeriatrics & GerontologyNeurosciencesNeurosciences & NeurologyElectroencephalographyOscillationsAgeAlphaAperiodic1fBRAIN-WAVE FREQUENCYALZHEIMERS-DISEASEREACTION-TIMEPREFRONTAL CORTEXCORTICAL RHYTHMSPEAK FREQUENCYRESPONSE-TIMEPOWER SPECTRASTATEOSCILLATIONS1/fHumansAgedAgingRestClinical ResearchClinical Sciences not elsewhere classifiedNeurosciences not elsewhere classified
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