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Do malignant cells sleep at night?

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journal contribution
posted on 2020-12-01, 00:00 authored by Luis Enrique Cortés-Hernández, Zahra Eslami-S, Antoine Dujon, Mathieu Giraudeau, Beata UjvariBeata Ujvari, Frédéric Thomas, Catherine Alix-Panabières
Biological rhythms regulate the biology of most, if not all living creatures, from whole organisms to their constitutive cells, their microbiota, and also parasites. Here, we present the hypothesis that internal and external ecological variations induced by biological cycles also influence or are exploited by cancer cells, especially by circulating tumor cells, the key players in the metastatic cascade. We then discuss the possible clinical implications of the effect of biological cycles on cancer progression, and how they could be exploited to improve and standardize methods used in the liquid biopsy field.

History

Journal

Genome Biology

Volume

21

Article number

276

Publisher

BioMed Central [Springer Nature]

Location

London, Eng.

ISSN

1474-7596

eISSN

1474-760X

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2020, The Authors