ujvari-domalignantcells-2020.pdf (1.82 MB)
Do malignant cells sleep at night?
journal contribution
posted on 2020-12-01, 00:00 authored by Luis Enrique Cortés-Hernández, Zahra Eslami-S, Antoine Dujon, Mathieu Giraudeau, Beata UjvariBeata Ujvari, Frédéric Thomas, Catherine Alix-PanabièresBiological rhythms regulate the biology of most, if not all living creatures, from whole organisms to their constitutive cells, their microbiota, and also parasites. Here, we present the hypothesis that internal and external ecological variations induced by biological cycles also influence or are exploited by cancer cells, especially by circulating tumor cells, the key players in the metastatic cascade. We then discuss the possible clinical implications of the effect of biological cycles on cancer progression, and how they could be exploited to improve and standardize methods used in the liquid biopsy field.
History
Journal
Genome BiologyVolume
21Article number
276Publisher
BioMed Central [Springer Nature]Location
London, Eng.Publisher DOI
Link to full text
ISSN
1474-7596eISSN
1474-760XLanguage
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2020, The AuthorsUsage metrics
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No categories selectedKeywords
Circadian cycleTumor disseminationCirculating tumor cellsChronobiologyDisease ecologyPhenologyScience & TechnologyLife Sciences & BiomedicineBiotechnology & Applied MicrobiologyGenetics & HeredityCIRCADIAN CLOCK GENESBREAST-CANCERVITAMIN-DPROSTATE-CANCERTUMOR-CELLSRISKDURATIONRHYTHMMELATONININTERLEUKIN-6
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