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Docosahexaenoic Acid Explains the Unexplained in Visual Transduction

journal contribution
posted on 2023-12-19, 03:36 authored by MA Crawford, Andrew SinclairAndrew Sinclair, Y Wang, WF Schmidt, CL Broadhurst, SC Dyall, L Horn, JT Brenna, MR Johnson
In George Wald’s Nobel Prize acceptance speech for “discoveries concerning the primary physiological and chemical visual processes in the eye”, he noted that events after the activation of rhodopsin are too slow to explain visual reception. Photoreceptor membrane phosphoglycerides contain near-saturation amounts of the omega-3 fatty acid docosahexaenoic acid (DHA). The visual response to a photon is a retinal cis–trans isomerization. The trans-state is lower in energy; hence, a quantum of energy is released equivalent to the sum of the photon and cis–trans difference. We hypothesize that DHA traps this energy, and the resulting hyperpolarization extracts the energized electron, which depolarizes the membrane and carries a function of the photon’s energy (wavelength) to the brain. There, it contributes to the creation of the vivid images of our world that we see in our consciousness. This proposed revision to the visual process provides an explanation for these previously unresolved issues around the speed of information transfer and the purity of conservation of a photon’s wavelength and supports observations of the unique and indispensable role of DHA in the visual process.

History

Journal

Entropy

Volume

25

Pagination

1520-1520

Location

Switzerland

ISSN

1099-4300

eISSN

1099-4300

Language

en

Issue

11

Publisher

MDPI AG