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Does maternal nutrition in pregnancy and birth weight influence levels of CHD risk factors in adult life?

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journal contribution
posted on 01.03.2004, 00:00 authored by Rachel HuxleyRachel Huxley, H Andrew W Neil
The fetal-origins hypothesis suggests that maternal and fetal nutrition can have a profound and sustained impact on the health of the offspring in adult life. Although there is abundant literature reporting on the associations between birth weight and disease risk factors, only a handful of studies have been able to examine the relationship between maternal nutrition in pregnancy with the health of offspring in adult life directly. Between 1942 and 1944, nearly 400 pregnant women were recruited into a dietary study to determine whether the wartime dietary rations were sufficient to prevent nutritional deficiencies. Detailed biochemical and clinical assessments were conducted for each of the women, who were followed-up until after delivery. More than 50 years later, approximately one-quarter of the adult offspring were recruited into a study to explore the possible impact of maternal nutrition in pregnancy on CHD risk factors, including glucose tolerance, blood pressure and components of the lipid profile. Results from the present study provide no evidence to support the hypothesis that birth weight or maternal nutrition in pregnancy are associated with CHD risk factors in adult life.

History

Journal

British Journal of Nutrition

Volume

91

Issue

3

Pagination

459 - 468

Publisher

Cambridge University Press

Location

Cambridge, Eng.

ISSN

0007-1145

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2004, Nutrition Society