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Does the longer application of anodal-transcranial direct current stimulaiton increase corticomotor excitability further? A pilot study

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Version 2 2024-06-17, 08:23
Version 1 2014-10-28, 10:04
journal contribution
posted on 2024-06-17, 08:23 authored by S Jaberzadeh, A Bastani, D Kidgell
Introduction: Anodal transcranial direct current stimulation (a-tDCS) of the primary motor cortex (M1) has been shown to be effective in increasing corticomotor excitability.
 
Methods: We investigated whether longer applications of a-tDCS coincide with greater increases in corticomotor excitability compared to shorter application of a-tDCS. Ten right-handed healthy participants received one session of a-tDCS (1mA current) with shorter (10 min) and longer (10+10 min) stimulation durations applied to the left M1 of extensor carpi radialis muscle (ECR). Corticomotor excitability following application of a-tDCS was assessed at rest with transcranial magnetic stimulation (TMS) elicited motor evoked potentials (MEP) and compared with baseline data for each participant.
 
Results: MEP amplitudes were increased following 10 min of a-tDCS by 67% (p = 0.001) with a further increase (32%) after the second 10 min of a-tDCS (p = 0.005). MEP amplitudes remained elevated at 15 min post stimulation compared to baseline values by 65% (p = 0.02).
 
Discussion: The results demonstrate that longer application of a-tDCS within the recommended safety limits, increases corticomotor excitability with after effects of up to 15 minutes post stimulation.

History

Journal

Basic and clinical neuroscience

Volume

3

Pagination

28-35

Location

Tehran, Iran

Open access

  • Yes

ISSN

2228-7442

eISSN

2008-126X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2012, Tehran University of Medical Sciences

Issue

4

Publisher

Tehran University of Medical Sciences

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