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Domino Heck-Aza-Michael reactions : efficient access to 1-substituted tetrahydro-β-carbolines
journal contributionposted on 2010-03-05, 00:00 authored by Daniel Priebbenow, Luke HendersonLuke Henderson, Fred PfefferFred Pfeffer, S Stewart
A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-β-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.