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Dopamine Reuptake Inhibition Modulates Antidepressant Response, mTor Signaling, and D2R Expression in a Rat Model of Treatment-Resistance

journal contribution
posted on 2016-05-01, 00:00 authored by Rajas R Kale, Abbas KouzaniAbbas Kouzani, Ken WalderKen Walder, Michael BerkMichael Berk, Susannah J Tye
Background: Dopamine plays an important role in antidepressant treatment-resistance. In the adrenocorticotropic hormone (ACTH) model of treatment-resistant depression, we therefore assessed the role of dopamine reuptake inhibition on antidepressant response, locomotor activity, mTOR signaling and dopamine D2receptor (D2R) protein expression.

History

Journal

Biological Psychiatry

Volume

79

Pagination

198S-199S

Location

Philadelphia, Pa.

ISSN

0006-3223

eISSN

1873-2402

Language

eng

Publication classification

X Not reportable, E3 Extract of paper

Issue

9 - 71st Annual Scientific Convention and Meeting

Publisher

Elsevier

Publication URL

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    Keywords

    Science & TechnologyLife Sciences & BiomedicineNeurosciencesPsychiatryNeurosciences & NeurologyTreatment-ResistanceACTHDopaminemTORRat110999 Neurosciences not elsewhere classified920410 Mental HealthFaculty of Science Engineering and Built EnvironmentSchool of Engineering3209 Neurosciences420313 Mental health services

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