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Dromedaries (Camelus dromedarius) are of low susceptibility to inoculation with foot-and-mouth disease virus serotype O
journal contribution
posted on 2008-11-01, 00:00 authored by Soren AlexandersenSoren Alexandersen, U Wernery, P Nagy, T Frederiksen, P NormannTwo sheep and five dromedaries were inoculated with a highdose of a cattle-passaged type O strain of foot-and-mouth disease virus (FMDV). The sheep developed typical FMD. The inoculated camels, which were placed in contact with five further dromedaries and four sheep, showed no visible signs of illness or vesicular lesions. However, one of them had a raised body temperature at 3 days post-inoculation (pi) and a viraemia from days 2 to 10; probang samples from this animal were negative for infectious virus, but a low level of FMDV RNA was detected in a sample taken on day 6 pi, five other samples taken from days 3 to 28 being negative. Examination of mouth swabs indicated a low level of FMDV RNA at days 1-5 pi in four of the five inoculated camels, but no infectious FMDV or FMDV RNA was detected in serum, probang or mouth swab samples from contact-exposed animals (camels and sheep). All the contact-exposed camels and sheep and two of the inoculated camels were serologically negative for FMD when tested up to day 28. In contrast, the camel with viraemia became serologically positive from day 14, and the other two inoculated camels (which had been exposed to FMDV in an earlier experiment) became serologically positive from day 10. The experiment suggested that dromedaries (1) are of low susceptibility to FMDV serotype O, (2) do not transmit infection, even by close contact, and (3) are unlikely to play a significant epidemiological role in FMD.
History
Journal
Journal of Comparative PathologyVolume
139Issue
4Pagination
187 - 193Publisher
ElsevierLocation
London, Eng.Publisher DOI
ISSN
0021-9975Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2008, ElsevierUsage metrics
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AnimalsAntibodies, ViralCamelCamelus dromedariusCattleDisease SusceptibilityDromedaryEnzyme-Linked Immunosorbent AssayFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusRNA, ViralReverse Transcriptase Polymerase Chain ReactionSheepSheep, DomesticViral infectionScience & TechnologyLife Sciences & BiomedicinePathologyVeterinary SciencesLINKED-IMMUNOSORBENT-ASSAYRT-PCR ASSAYREAL-TIMEDIAGNOSISPATHOGENESISANTIBODIESGROWTHCELLS
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