File(s) under permanent embargo

Dysglycaemia and other predictors for progression or regression from impaired fasting glucose to diabetes or normoglycaemia

journal contribution
posted on 01.01.2015, 00:00 authored by L De Abreu, Kara KewKara Kew, Mark KotowiczMark Kotowicz, Julie PascoJulie Pasco
Aims. Diabetes mellitus is a growing health problem worldwide. This study aimed to describe dysglycaemia and determine the impact of body composition and clinical and lifestyle factors on the risk of progression or regression from impaired fasting glucose (IFG) to diabetes or normoglycaemia in Australian women. Methods. This study included 1167 women, aged 20-94 years, enrolled in the Geelong Osteoporosis Study. Multivariable logistic regression was used to identify predictors for progression to diabetes or regression to normoglycaemia (from IFG), over 10 years of follow-up. Results. At baseline the proportion of women with IFG was 33.8% and 6.5% had diabetes. Those with fasting dysglycaemia had higher obesity-related factors, lower serum HDL cholesterol, and lower physical activity. Over a decade, the incidence of progression from IFG to diabetes was 18.1 per 1,000 person-years (95% CI, 10.7-28.2). Fasting plasma glucose and serum triglycerides were important factors in both progression to diabetes and regression to normoglycaemia. Conclusions. Our results show a transitional process; those with IFG had risk factors intermediate to normoglycaemics and those with diabetes. This investigation may help target interventions to those with IFG at high risk of progression to diabetes and thereby prevent cases of diabetes.

History

Journal

Journal of diabetes research

Volume

2015

Article number

373762

Pagination

1 - 8

Publisher

Hindawi Publishing Corporation

Location

New York, N. Y.

ISSN

2314-6745

eISSN

2314-6753

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2015, The Authors