ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish
Version 2 2024-06-04, 02:11Version 2 2024-06-04, 02:11
Version 1 2014-11-12, 14:56Version 1 2014-11-12, 14:56
journal contribution
posted on 2024-06-04, 02:11 authored by P Rasighaemi, SM Onnebo, Clifford LiongueClifford Liongue, Alister WardAlister WardChromosomal translocations involving fusions of the human ETV6 (TEL1) gene occur frequently in hematologic malignancies. However, a detailed understanding of the normal function of ETV6 remains incomplete. This study has employed zebrafish as a relevant model to investigate the role of ETV6 during embryonic hematopoiesis. Zebrafish possessed a single conserved etv6 ortholog that was expressed from 12 hpf in the lateral plate mesoderm, and later in hematopoietic, vascular and other tissues. Morpholino-mediated gene knockdown of etv6 revealed the complex contribution of this gene toward embryonic hematopoiesis. During primitive hematopoiesis, etv6 knockdown resulted in reduced levels of progenitor cells, erythrocyte and macrophage populations, but increased numbers of incompletely differentiated heterophils. Definitive hematopoiesis was also perturbed, with etv6 knockdown leading to decreased erythrocytes and myeloid cells, but enhanced lymphopoiesis. This study suggests that ETV6 plays a broader and more complex role in early hematopoiesis than previously thought, impacting on the development of multiple lineages. © 2015 Ferrata Storti Foundation.
History
Journal
HaematologicaVolume
100Pagination
23-31Location
Pavia, ItalyPublisher DOI
ISSN
0390-6078eISSN
1592-8721Language
engPublication classification
C1 Refereed article in a scholarly journal, C Journal articleCopyright notice
2014, Fondazione Ferrata StortiIssue
1Publisher
Fondazione Ferrata StortiUsage metrics
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