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EVIDENCE FOR A FUNCTIONAL CENTRAL DOPAMINERGIC INSUFFICIENCY IN THE SPONTANEOUSLY HYPERTENSIVE RAT

Version 2 2024-06-17, 13:41
Version 1 2015-08-14, 12:27
journal contribution
posted on 2024-06-17, 13:41 authored by JS HUTCHINSON, R DINICOLANTONIO, M VERONI, M CLEVERDON
Several neuroendocrine abnormalities reported in the spontaneously hypertensive rat (SHR) suggest that the function of the dopaminergic tuberoinfundibular tract is impaired in this strain. SHR were pretreated with the peripheral acting inhibitor of dopa decarboxylase, carbidopa, or vehicle. Intravenous injection of L-dopa, the precursor of dopamine, lowered blood pressure only in the carbidopa treated SHR suggesting a central dopamine action. Intracerebroventricular injection of dopamine in SHR lowered blood pressure towards normal. The data are in agreement with the hypothesis that SHR have a functional central dopaminergic insufficiency.

History

Journal

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Volume

10

Pagination

311-314

Location

Australia

ISSN

0305-1870

eISSN

1440-1681

Language

English

Publication classification

CN.1 Other journal article

Issue

3

Publisher

BLACKWELL SCIENCE