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Early SARS-CoV-2-associated acute transverse myelitis: A case for neurotropism?

journal contribution
posted on 24.11.2022, 03:53 authored by IF Lu, JS Cornish, A Ashok, SK Chen, Eugene AthanEugene Athan, Andrew HughesAndrew Hughes
There are increasing reports of immune-mediated and para-infectious syndromes beyond the well-known respiratory manifestations of severe-acute-respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the spectrum of severe neurological sequelae of SARS-CoV-2 remains undefined. We present the case of a 66-year-old female with rapidly progressive lower limb neurology 3 days post SARS-CoV-2 infection. Clinical and radiological findings were in keeping with transverse myelitis and treatment success was achieved with methylprednisolone and remdesivir. This report will discuss the associations between SARS-CoV-2 and acute transverse myelitis. We believe this is one of few described cases of early SARS-CoV-2-associated transverse myelitis secondary to neurotropism and the first successfully treated with the inclusion of remdesivir in the therapeutic regimen.

History

Journal

Journal of Internal Medicine

Volume

292

Pagination

679-683

Location

London, Eng.

ISSN

0954-6820

eISSN

1365-2796

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Issue

4

Publisher

Wiley