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Early clinical markers of overweight/obesity onset and resolution by adolescence

journal contribution
posted on 01.01.2020, 00:00 authored by Markus Juonala, Ted Lau, Melissa Wake, Anneke Grobler, Jessica A Kerr, Costan G Magnussen, Matthew A Sabin, David P Burgner, Kate LycettKate Lycett
Objectives
We examined how combinations of clinical indicators at various ages predict overweight/obesity development, as well as resolution, by 10–11 and 14–15 years of age.

Methods
Data were derived from Birth (N = 3469) and Kinder (N = 3276) cohorts of the Longitudinal Study of Australian Children, followed from ages 2–3 and 4–5 years, respectively. Every two years, 25 potential obesity-relevant clinical indicators were quantified. Overweight/obesity was defined using International Obesity Taskforce cutpoints at 10–11 years and 14–15 years.

Results
In both cohorts, three factors predicted both development and resolution of overweight/obesity in multivariable models. Among normal weight children, increased odds of developing overweight/obesity were associated with higher child (odd ratio (OR) 1.67–3.35 across different study waves) and maternal (OR 1.05–1.09) BMI, and inversely with higher maternal education (OR 0.60–0.62, when assessed at age 2–7 years). Lower odds of resolving existing overweight/obesity were related with higher child (OR 0.51–0.79) and maternal (OR 0.89–0.95) BMI, and inversely with higher maternal education (OR 1.62–1.92, when assessed at age 2–5 years). The prevalence of overweight/obesity at the age of 14–15 years was 13% among children with none of these risk factors at age 6–7 years, compared with 71% among those with all 3 risk factors (P < 0.001).

Conclusions
From early childhood onwards, child and maternal BMI and maternal education predict overweight/obesity onset and resolution by adolescence. A simple risk score, easily available to child health clinicians, could help target treatment or prevention.

History

Journal

International journal of obesity

Volume

44

Pagination

82 - 93

Publisher

Springer Science and Business Media LLC

Location

New York, N.Y.

ISSN

0307-0565

eISSN

1476-5497

Language

eng

Publication classification

C1 Refereed article in a scholarly journal