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Effect of increased blood glucose availability on glucose kinetics during exercise
journal contribution
posted on 1998-04-01, 00:00 authored by Kirsten HowlettKirsten Howlett, D Angus, J Proietto, Mark HargreavesThis study examined the effect of increased blood glucose availability on glucose kinetics during exercise. Five trained men cycled for 40 min at 77 ± 1% peak oxygen uptake on two occasions. During the second trial (Glu), glucose was infused at a rate equal to the average hepatic glucose production (HGP) measured during exercise in the control trial (Con). Glucose kinetics were measured by a primed continuous infusion ofd-[3-3H]glucose. Plasma glucose increased during exercise in both trials and was significantly higher in Glu. HGP was similar at rest (Con, 11.4 ± 1.2; Glu, 10.6 ± 0.6 μmol ⋅ kg−1 ⋅ min−1). After 40 min of exercise, HGP reached a peak of 40.2 ± 5.5 μmol ⋅ kg−1 ⋅ min−1in Con; however, in Glu, there was complete inhibition of the increase in HGP during exercise that never rose above the preexercise level. The rate of glucose disappearance was greater (P < 0.05) during the last 15 min of exercise in Glu. These results indicate that an increase in glucose availability inhibits the rise in HGP during exercise, suggesting that metabolic feedback signals can override feed-forward activation of HGP during strenuous exercise.
History
Journal
Journal of applied physiologyVolume
84Issue
4Pagination
1413 - 1417Publisher
American Physiological SocietyLocation
Bethesda, Md.ISSN
8750-7587eISSN
1522-1601Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1998, American Physiological SocietyUsage metrics
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