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Effect of inorganic nitrate on exercise capacity, mitochondria respiration, and vascular function in heart failure with reduced ejection fraction

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Version 2 2024-06-03, 10:12
Version 1 2021-10-20, 08:29
journal contribution
posted on 2024-06-03, 10:12 authored by MN Woessner, C Neil, NJ Saner, CA Goodman, LC McIlvenna, JO De Zevallos, Andrew GarnhamAndrew Garnham, I Levinger, JD Allen
This is the largest study to date to examine the effects of inorganic nitrate supplementation in patients with heart failure with reduced ejection fraction (HFrEF) and the first to include measures of vascular function and mitochondrial respiration. Although daily supplementation increased plasma nitrite, our data indicate that supplementation with inorganic nitrate as a standalone treatment is ineffective at improving exercise capacity, vascular function, or mitochondrial respiration in patients with HFrEF.

History

Journal

Journal of Applied Physiology

Volume

128

Pagination

1355-1364

Location

Rockville, Md.

Open access

  • Yes

ISSN

8750-7587

eISSN

1522-1601

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Issue

5

Publisher

American Physiological Society