File(s) under permanent embargo
Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig
journal contribution
posted on 2003-01-01, 00:00 authored by Karen L Kind, Peter M Clifton, Patricia A Grant, Phillip C Owens, Annica Sohlstrom, Claire T Roberts, Jeffrey S Robinson, Julie OwensJulie OwensMaternal nutrient restriction and impaired fetal growth are associated with postnatal insulin resistance, hyperinsulinemia, and glucose intolerance in humans but not consistently in other species, such as the rat or sheep. We therefore determined the effect of mild (85% ad libitum intake/kg body wt) or moderate (70% ad libitum intake/kg body wt) maternal feed restriction throughout pregnancy on glucose and insulin responses to an intravenous glucose tolerance test (IVGTT) in the young adult guinea pig. Maternal feed restriction reduced birth weight (mild and moderate: both P < 0.02) in male offspring. Moderate restriction increased plasma glucose area under the curve (P < 0.04) and decreased the glucose tolerance index (K(G)) (P < 0.02) during the IVGTT in male offspring compared with those of mildly restricted but not of ad libitum-fed mothers. Moderate restriction increased fasting plasma insulin (P < 0.04, adjusted for litter size) and the insulin response to IVGTT (P < 0.001), and both moderate and mild restriction increased the insulin-to-glucose ratio during the IVGTT (P < 0.003 and P < 0.02) in male offspring. When offspring were classed into tertiles according to birth weight, glucose tolerance was not altered, but fasting insulin concentrations were increased in low compared with medium birth weight males (P < 0.03). The insulin-to-glucose ratio throughout the IVGTT was increased in low compared with medium (P < 0.01) or high (P < 0.05) birth weight males. Thus maternal feed restriction in the guinea pig restricts fetal growth and causes hyperinsulinemia in young adult male offspring, suggestive of insulin resistance. These findings suggest that mild to moderate prenatal perturbation programs postnatal glucose homeostasis adversely in the guinea pig, as in the human.
History
Journal
American journal of physiology: regulatory, integrative and comparative physiologyVolume
284Issue
1Pagination
R140 - R152Publisher
American Physiological SocietyLocation
Bethesda, Md.Publisher DOI
ISSN
0363-6119Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2003, American Physiological SocietyUsage metrics
Categories
No categories selectedKeywords
AgingAnimalsBirth WeightBlood GlucoseBody CompositionCaloric RestrictionFemaleFood DeprivationGlucoseGlucose Tolerance TestGuinea PigsInsulinInsulin ResistanceMalePregnancyPregnancy, AnimalPrenatal Exposure Delayed EffectsScience & TechnologyLife Sciences & BiomedicinePhysiologyintravenous glucose tolerance testplasma insulinINTRAUTERINE GROWTH-RETARDATIONINSULIN-RESISTANCEFETAL GROWTHIN-UTERODIABETES-MELLITUSINFANT GROWTHBIRTHSIZERATSCHILDHOOD
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC