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Effect of variable long-term maternal feed allowance on the development of the ovine placenta and fetus
journal contribution
posted on 2008-06-01, 00:00 authored by S P Quigley, D O Kleemann, S K Walker, P A Speck, S R Rudiger, G S Nattrass, M J DeBlasio, Julie OwensJulie OwensMaternal feed allowance during pregnancy can affect the development of the ovine placenta and fetus. The impact of variations in feed allowance prior to as well as throughout pregnancy has received less attention. Ewes were offered 0.6 (R), 1.2 (C) or 1.8 (AL) maintenance requirements from 89 days before conception until day 133 of pregnancy. Ewes were euthanised on days 50, 92 and 133 of pregnancy. Ewe live weight and body condition score, maternal and fetal metabolic and hormonal profiles, fetal body dimensions and organ weights, and the number, weight and morphology of placentomes were measured. Maternal live weight and condition score were lower in R compared to AL ewes at all stages of pregnancy (P<0.05). Plasma glucose and albumin concentrations of R ewes were significantly reduced (P<0.05) at mid and late gestation, respectively. Placental components were generally unresponsive to long term variations in maternal feed allowance. However, placental weight was significantly (P<0.05) correlated with fetal weight at days 50 (r=0.59) and 133 (r=0.69) of gestation. By late gestation growth-retarded singleton fetuses from R ewes were 19% lighter (P<0.05), with reduced abdominal (9%) and thoracic (10%) girths (P<0.05) but of similar crown-rump length compared with fetuses from AL ewes. These differences were associated with significantly reduced IGF-I concentrations in fetal plasma (P<0.05). In conclusion, maternal, placental and fetal adaptations to long established planes of variable maternal feed allowance were able to maintain fetal growth during early and mid-pregnancy while fetal growth restriction, associated with reduced fetal IGF-I levels, became apparent in late pregnancy.
History
Journal
PlacentaVolume
29Issue
6Pagination
539 - 548Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0143-4004Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2008, Elsevier Ltd.Usage metrics
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No categories selectedKeywords
Animal FeedAnimal Nutritional Physiological PhenomenaAnimalsBlood GlucoseBody ConstitutionBody WeightFatty Acids, NonesterifiedFemaleFetal DevelopmentFetal WeightMaternal Nutritional Physiological PhenomenaMaternal-Fetal ExchangeMusclesOrgan SizePlacentationPregnancyPregnancy, AnimalSheepTime FactorsUreaScience & TechnologyLife Sciences & BiomedicineDevelopmental BiologyObstetrics & GynecologyReproductive BiologynutritionGROWTH-FACTOR-IFETAL SHEEPNUTRIENT RESTRICTIONLATE-GESTATIONPOSTNATAL NUTRITIONBINDING-PROTEINSADOLESCENT SHEEPSKELETAL-MUSCLENEONATAL SHEEPMID GESTATION
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