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Effect of zinc supplementation on the immune status of healthy older individuals aged 55–70 years : the ZENITH Study

journal contribution
posted on 2007-06-01, 00:00 authored by C Hodkinson, M Kelly, H Alexander, I Bradbury, P Robson, M Bonham, J O'Connor, C Coudray, J Strain, J Wallace
Aging is associated with alterations in the immune system, effects which may be exacerbated by inadequate zinc (Zn) status. We examined the relationship between Zn status and markers of immunity and the effect of supplementation with 15 mg or 30 mg Zn/d for 6 months on immune status in healthy individuals. Zn status was assessed by dietary intake and biochemical indices. Immune status was assessed by multiple flow cytometric methods. At baseline, Zn concentration was positively associated with lymphocyte subpopulation counts and T-lymphocyte activation. Zn supplementation of 30 mg/d significantly lowered B-lymphocyte count, albeit at month 3 only. Lower doses of Zn (15 mg Zn/d) significantly increased the ratio of CD4 to CD8 T lymphocytes at month 6. Overall, these findings suggest that total Zn intake (diet plus supplementation) of up to 40 mg Zn/d do not have significant long-term effects on immune status in apparently healthy persons aged 55–70 years.

History

Journal

The journals of gerontology. series A, biological sciences and medical sciences

Volume

62A

Issue

6

Pagination

598 - 608

Publisher

Oxford University Press

Location

Cary, N.C.

ISSN

1079-5006

eISSN

1758-535X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal; C Journal article

Copyright notice

2007, The Gerontological Society of America

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