INTRODUCTION AND AIMS: The relationship between alcohol intoxication and harm is well known, and many community-based interventions have been introduced in an attempt to reduce the rates of alcohol-related harm. The current paper uses two metropolitan and two regional Australian cities as sites to investigate the impact of community-based interventions on the reduction of alcohol-related harms. DESIGN AND METHODS: Data for injury-related emergency department (ED) presentations and police attended assaults during high-alcohol hours (i.e. 20:00-06:00 h, Friday and Saturday nights) were obtained for each site from 2000 to 2015 for ED presentations and from 2000 to 2016 for police assaults. Autoregressive integrated moving average time series analyses were conducted to determine the impact of the community-based interventions introduced at each site for reducing these rates of ED injury presentations and police attended assaults. RESULTS: None of the community-level interventions that were introduced across the four sites resulted in a reduction in ED presentation rates or assault rates. DISCUSSION AND CONCLUSIONS: The majority of interventions introduced across the four sites were proposed and implemented by local liquor accords. Given none of the interventions demonstrated a reduction in ED injury presentation rates or police attended assault rates, it is argued that local liquor accords may not be best placed to propose alcohol-related harm reduction measures, and instead, there should be a focus on the implementation of evidence-based regulatory strategies, such as restricted trading hours. [Curtis A, Coomber K, Droste N, Hyder S, Palmer D, Miller PG. Effectiveness of community-based interventions for reducing alcohol-related harm in two metropolitan and two regional sites in Victoria, Australia. Drug Alcohol Rev 2017;36:359-368].