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Effects of acute and chronic food restriction on the insulin-like growth factor axis in the guinea pig
journal contribution
posted on 1998-04-01, 00:00 authored by A Sohlström, A Katsman, K L Kind, P A Grant, P C Owens, J S Robinson, Julie OwensThe effect of fasting (17-18 h) versus food restriction (70% for 80 +/- 13 days) on the IGF-IGF binding protein (BP) axis in female guinea pigs was studied and related to body weight, weight gain and food conversion efficiency. Circulating IGF-I was reduced in the fasted (13%) and food-restricted (50%) animals. IGF-II was only decreased (61%) in the food-restricted group. There was no effect of fasting on IGFBP-1 to -4 while IGFBP-1, -3 and -4 were reduced by 56%, 60% and 44% respectively, and IGFBP-2 increased by 72%, in the food-restricted group. Food restriction reduced the relative sizes of fat depots, spleen, liver, thymus and heart, increased those of adrenals, kidneys, pancreas, gastrointestinal tract, M. Biceps, M. Soleus and brain while those of uterus, lungs, thyroids and M. Gastrocnemius were unchanged. IGFBP-1 and -2 were negatively correlated to weight gain and food conversion efficiency in the ad libitum-fed group, while IGF-I, -II, IGFBP-1, -3 and -4 were positively correlated to body weight, weight gain and food conversion efficiency in the food-restricted group. The results show that acute and chronic food restriction have different consequences for the IGF-IGFBP axis. Furthermore, IGF-II as well as IGF-I are implicated in the control of body weight, weight gain and food conversion efficiency under conditions of restricted nutrition. Finally, IGFBP-1 and -2 may have different roles during chronic undernutrition compared with unrestrained nutrition in adult life.
History
Journal
Journal of endocrinologyVolume
157Issue
1Pagination
107 - 114Publisher
BioscientificaLocation
Bradley Stok, Eng.ISSN
0022-0795eISSN
1479-6805Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1998, Journal of Endocrinology LtdUsage metrics
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AnimalsBlood GlucoseBlotting, WesternCholesterolFastingFatty AcidsFemaleFood DeprivationGuinea PigsInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 2Insulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding Protein 4Insulin-Like Growth Factor Binding ProteinsInsulin-Like Growth Factor IInsulin-Like Growth Factor IILactic AcidOrgan SizeRadioimmunoassaySomatomedinsWeight GainScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismFACTOR-BINDING-PROTEINSI IGF-IVITAMIN-C-DEFICIENTNUTRITIONAL REGULATIONHORMONE SECRETIONGROWING-PIGSSERUMINFUSIONPLASMAMALNUTRITION
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