Deakin University
Browse

File(s) under permanent embargo

Effects of aging, exercise, and disease on force transfer in skeletal muscle

journal contribution
posted on 2015-07-01, 00:00 authored by D C Hughes, Marita Wallace, K Baar
The loss of muscle strength and increased injury rate in aging skeletal muscle has previously been attributed to loss of muscle protein (cross-sectional area) and/or decreased neural activation. However, it is becoming clear that force transfer within and between fibers plays a significant role in this process as well. Force transfer involves a secondary matrix of proteins that align and transmit the force produced by the thick and thin filaments along muscle fibers and out to the extracellular matrix. These specialized networks of cytoskeletal proteins aid in passing force through the muscle and also serve to protect individual fibers from injury. This review discusses the cytoskeleton proteins that have been identified as playing a role in muscle force transmission, both longitudinally and laterally, and where possible highlights how disease, aging, and exercise influence the expression and function of these proteins.

History

Journal

American journal of physiology - endocrinology and metabolism

Volume

309

Issue

1

Pagination

1 - 10

Publisher

American Physiological Society

Location

Bethesda, Md.

ISSN

0193-1849

eISSN

1522-1555

Language

eng

Publication classification

C Journal article; C1.1 Refereed article in a scholarly journal

Copyright notice

2015, American Physiological Society

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC