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Effects of variation in modulator temperature during cryogenic modulation in comprehensive two-dimensional gas chromatography
journal contribution
posted on 2009-09-01, 00:00 authored by F Begnaud, C Debonneville, J P Probst, A Chaintreau, P Morrison, Jacqui AdcockJacqui Adcock, P MarriottMany modulation systems in comprehensive 2D GC (GC×GC) are based on cryogenic methods. High trapping temperatures in these systems can result in ineffective trapping of the more volatile compounds, whilst temperatures that are too low can prevent efficient remobilisation of some compounds. To better understand the trapping and release of compounds over a wide range of volatilities, we have investigated a number of different constant temperature modulator settings, and have also examined a constant temperature differential between the cryo-trap and the chromatographic oven. These investigations have led us to modify the temperature regulation capabilities of the longitudinally modulated cryogenic system (LMCS). In contrast to the current system, where the user sets a constant temperature for the cooling chamber, the user now sets the temperature difference between the cryo-trap and the chromatographic oven. In this configuration, the cooling chamber temperature increases during the chromatographic run, tracking the oven temperature ramp. This produces more efficient, volatility-dependent modulation, and increases the range of volatile compounds that can be analysed under optimal trap-and-release conditions within a single analytical run. This system also reduces cryogenic fluid consumption.
History
Journal
Journal of separation scienceVolume
32Issue
18Pagination
3144 - 3151Publisher
Wiley - V C H Verlag GmbH & Co. KGaALocation
Weinheim, GermanyPublisher DOI
ISSN
1615-9306eISSN
1615-9314Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2009 WILEY-VCH Verlag GmbH & Co. KGaAUsage metrics
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