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Efficacy and effectiveness of carnitine supplementation for cancer-related fatigue: A systematic literature review and meta-analysis

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Version 2 2024-06-04, 14:21
Version 1 2018-05-30, 17:11
journal contribution
posted on 2024-06-18, 06:50 authored by Wolf MarxWolf Marx, L Teleni, Rachelle Opie, J Kelly, S Marshall, C Itsiopoulos, E Isenring
Background: Carnitine deficiency has been implicated as a potential pathway for cancer-related fatigue that could be treated with carnitine supplementation. The aim of this systematic literature review and meta-analysis was to evaluate the literature regarding the use of supplemental carnitine as a tre atment for cancer-related fatigue. Methods: Using the PRISMA guidelines, an electronic search of the Cochrane Library, MEDLINE, Embase, CINAHL and reference lists was conducted. Data were extracted and independently assessed for quality using the Academy of Nutrition and Dietetics evidence analysis by two reviewers. In studies with positive quality ratings, a meta-analysis was performed using the random-effects model on Carnitine and cancer-related fatigue. Results: Twelve studies were included for review with eight reporting improvement in measures of fatigue, while four reported no benefit. However, many studies were non-randomized, open-label and/or used inappropriate dose or comparators. Meta-analysis was performed in three studies with sufficient data. Carnitine did not significantly reduce cancer-related fatigue with a standardized mean difference (SMD) of 0.06 points ((95% CI −0.09, 0.21); p = 0.45). Conclusion: Results from studies with lower risk of bias do not support the use of carnitine supplementation for cancer-related fatigue.

History

Journal

Nutrients

Volume

9

Article number

ARTN 1224

Location

Switzerland

Open access

  • Yes

ISSN

2072-6643

eISSN

2072-6643

Language

English

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2017, The Authors

Issue

11

Publisher

MDPI