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Efficacy of traditional Chinese medicine for the management of constipation: a systematic review

journal contribution
posted on 2009-12-15, 00:00 authored by L-W Lin, Y-T Fu, Patricia Dunning, A L Zhang, T-H Ho, Maxine DukeMaxine Duke, S K Lo
OBJECTIVES: The aim of this systematic review was to critically appraise published clinical trials designed to assess the effect of Traditional Chinese Medicine (TCM) on the management of constipation. METHODS: Databases searched included both English and non-English articles published in the Cochrane library, MEDLINE, CINAHL, AMED, EMBASE, China National Knowledge Infrastructure (CNKI), and the Chinese Electronic Periodical Services (CEPS). Studies reviewed included randomized controlled trials and controlled clinical trials. Methodological quality was assessed using the modified Jadad scale. RESULTS: One hundred and thirty-seven (137) studies met the inclusion criteria, of which 21 were high-quality trials (n = 2449). Eighteen (18) were Chinese herbal medicine (CHM) and 3 were acupuncture trials. The primary outcome measure was total effective rate. CHM was more effective than conventional medicines in eight trials. Of the 10 remaining CHM trials, 9 compared the study CHM with another CHM and the results were significant in 4 trials. The effective rate was significantly higher in the intervention group than in the placebo group in the last CHM study. One (1) of the three acupuncture trials compared acupuncture with a conventional medicine, one trial with Sennae folium, and one trial with deeper acupuncture on Tianshu (ST 25). The therapeutic effect in the treatment group was more effective than that in the control group in all three studies. CONCLUSIONS: TCM interventions appear to be useful to manage constipation. Significant positive results were found in 15 high-quality studies. However, only 21 of the 137 publications identified attained high Jadad scores. There was heterogeneity in diagnostic procedures and interventions among the studies. Outcome indicators were also different. Hence, the results should be interpreted cautiously.

History

Journal

Journal of alternative and complementary medicine

Volume

15

Issue

12

Pagination

1335 - 1346

Publisher

Mary Ann Liebert Publishers

Location

New Rochelle, N.Y.

ISSN

1075-5535

eISSN

1557-7708

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2009, Mary Ann Liebert, Inc.