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Efficacy of vitamin d food fortification and biofortification in children and adults: A systematic review protocol
journal contribution
posted on 2023-04-19, 02:56 authored by E Dunlop, M Kiely, AP James, T Singh, LJ BlackObjective: The objective of this review is to assess the effect of vitamin D food fortification and biofortification on serum 25-hydroxyvitamin D (25(OH)D) concentrations. Introduction: Vitamin D deficiency is a global issue with considerable implications for public health. Many people do not receive sufficient sun exposure for adequate endogenous vitamin D synthesis, nor sufficient dietary vitamin D to meet their requirements. Increasing sun exposure may increase the risk of skin cancer, and vitamin D supplementation is not favored as a population-wide solution. Previous systematic reviews have shown a dose- dependent effect of vitamin D-fortified foods on circulating 25(OH)D concentrations. However, previous reviews did not investigate the efficacy of vitamin D fortification and biofortification in children, and several new fortification and biofortification trials in adults have been published since these earlier systematic reviews were conducted. Inclusion criteria: This review will consider randomized controlled trials that investigate the effect of vitamin D food fortification and biofortification on serum 25(OH)D concentrations in children and adults. Methods: CINAHL, MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and PubMed will be searched for relevant studies published in English. Following a screening of titles and abstracts by a single author, relevant fulltext articles will be independently reviewed by two authors. Two authors will independently assess methodological quality using the JBI critical appraisal checklist for randomized controlled trials. Data will be independently extracted by two authors. A meta-analysis will be conducted, and heterogeneity will be statistically tested. Systematic review registration number: PROSPERO CRD42020145497.
History
Journal
JBI Evidence SynthesisVolume
18Pagination
2694-2703Location
United StatesPublisher DOI
ISSN
2689-8381eISSN
2689-8381Language
enIssue
12Publisher
Ovid Technologies (Wolters Kluwer Health)Usage metrics
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No categories selectedKeywords
AdultBiofortificationChildFood, FortifiedHumansMeta-Analysis as TopicSystematic Reviews as TopicVitamin DVitamin D DeficiencyVitamins25-hydroxyvitamin Dbiofortificationfoodfortificationvitamin DClinical ResearchClinical Trials and Supportive ActivitiesComplementary and Integrative HealthNutritionCancerPrevention3.3 Nutrition and chemoprevention3 Prevention of disease and conditions, and promotion of well-being2 Zero Hunger
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