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Electrical Stimulation of Myoblast Proliferation and Differentiation on Aligned Nanostructured Conductive Polymer Platforms
journal contributionposted on 2012-01-01, 00:00 authored by A Quigley, Joselito RazalJoselito Razal, M Kita, R Jalili, A Gelmi, A Penington, R Ovalle-Robles, R Baughman, G Clark, G Wallace, R Kapsa
In this study, nanostructured conductive platforms synthesized from aligned multiwalled carbon nanotubes and polypyrrole are investigated as myo-regenerative scaffolds. Myotube formation follows a linear path on the platforms coinciding with extent of nanotopography. In addition, electrical stimulation enhances myo-nuclear number and differentiation. These studies demonstrate that conductive polymer platforms can be used to influence muscle cell behaviour through nanostructure and electrical stimulation.
JournalAdvanced Healthcare Materials
Pagination801 - 808
PublisherJohn Wiley and Sons Inc.
Publication classificationC1.1 Refereed article in a scholarly journal
Copyright notice2012, John Wiley & Sons
Conducting polymersElectrical stimulationNanostructuresMusclesGold nanoparticlesScience & TechnologyTechnologyEngineering, BiomedicalNanoscience & NanotechnologyMaterials Science, BiomaterialsEngineeringScience & Technology - Other TopicsMaterials ScienceCARBON NANOTUBE COMPOSITESKELETAL-MUSCLEBONE-FORMATIONPOLYPYRROLECELLSPROTEINGROWTHADHESIONGUIDANCESCAFFOLD