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Electrochemical selective detection of carnitine enantiomers coupling copper ion dependent DNAzyme with DNA assistant hybridization chain reaction

journal contribution
posted on 2019-03-15, 00:00 authored by F Zhai, Q Yu, H Zhou, Jing Liu, Wenrong YangWenrong Yang, J You
An electrochemical method for carnitine enantiomers recognition is proposed employing Cu (II)-L-cysteine complexes and signal amplification strategies based on DNAzyme and DNA assistant hybridization chain reaction (HCR). The reported method combined Cu (II)-amino acids complexes with DNAzyme and proposed a smart and efficient electrochemical method to recognize chiral molecules through the difference between homochiral interaction and heterochiral interaction. Moreover, further employment of hairpin DNA assistant HCR greatly enhanced the detecting signal, realizing the selective recognition of carnitine enantiomers in low concentrations. This study creatively provides a general sensing method for sensitive chiral molecules recognition without large-scale precision instruments.

History

Journal

Journal of electroanalytical chemistry

Volume

837

Pagination

137 - 142

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

1572-6657

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Elsevier B.V.