Electroretinograms of albino and pigmented guinea-pigs (Cavia porcellus)

Abstract Purpose/Methods: The present study compares the electroretinogram responses of albino and pigmented guinea‐pigs (Cavia porcellus) with data published for the rat and mouse. Results: We found that albino guinea‐pigs gave significantly larger amplitudes and faster implicit times for a‐wave and peak‐to‐peak responses than did pigmented animals. In contrast, pigmented and albino rats and mice do not show such differences between strains. Conclusion: We suggest that the guinea‐pig may be a better model of the retinal response in human albinism as their response characteristics are consistent with those published for humans.