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Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males

Version 2 2024-05-30, 15:29
Version 1 2015-03-18, 11:48
journal contribution
posted on 2024-05-30, 15:29 authored by CS Gama, M Salvador, AC Andreazza, MI Lobato, Michael BerkMichael Berk, F Kapczinski, PS Belmonte-de-Abreu
Impaired antioxidant defenses are suggested to participate in the pathophysiology of schizophrenia. Altered superoxide dismutase (SOD) and increased lipid peroxidation, measured by the thiobarbituric acid reactive substances (TBARS), are increased in schizophrenia. The aim of this study was to determine the effects of clinical course and subtype on oxidative stress parameters. In this study, 68 male patients, classified according to DSM-IV schizophrenia subtypes and clinical course (partial remission, marked symptoms, and deteriorated), were studied, and TBARS and SOD measured. Mean serum SOD and mean serum TBARS concentrations were similarly not significantly different among different subtypes (paranoid, disorganized and undifferentiated). However, marked symptoms status was associated with higher TBARS levels compared to the deteriorated group. This suggests a possible relationship between symptom acuity and oxidative stress in males.

History

Journal

Neuroscience Letters

Volume

433

Pagination

270-273

Location

Shannon, Clare Ireland

ISSN

0304-3940

eISSN

1872-7972

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2008, Elsevier Ireland

Issue

3

Publisher

Elsevier Ireland