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Emerging engineered magnetic nanoparticulate probes for molecular MRI of atherosclerosis : how far have we come?

journal contribution
posted on 2012-01-01, 00:00 authored by Rupinder Kanwar, Rajneesh Chaudhary, Takuya Tsuzuki, Jagat Kanwar
Atherosclerosis is a chronic, progressive, immunoinflammatory disease of the large and medium-sized arteries, and a major cause of cardiovascular diseases. Atherosclerosis often progresses silently for decades until the occurrence of a major catastrophic clinical event such as myocardial infarction, cardiac arrest and stroke. The main challenge in the diagnosis and management of atherosclerosis is to develop a safe, noninvasive technique that is accurate and reproducible, which can detect the biologically active high-risk vulnerable plaques (with ongoing active inflammation, angiogenesis and apoptosis) before the occurrence of an acute clinical event. This Journal Article reviews the events involved in the pathogenesis of atherosclerosis in light of recently advanced understanding of the molecular pathogenesis of the disease. Next, we elaborate on the interesting developments in molecular MRI, by describing the recently engineered magnetic nanoparticulate probes targeting clinically promising molecular and cellular players/processes, involved in early atherosclerotic lesion formation to plaque rupture and erosion.

History

Journal

Nanomedicine

Volume

7

Issue

6

Pagination

899 - 916

Publisher

Future Medicine

Location

London, England

ISSN

1743-5889

eISSN

1748-6963

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2012, Future Medicine